072 The release of extracellular vesicles in runners: a systematic review

Extracellular vesicles (EV) are thought to mediate the systemic adaptations physical exercise including running. In this systematic review, we aimed analyze kinetics of EV release in peripheral blood runners. We searched Pubmed, Scopus and Web Science using search strategy [‘Extracellular vesicles’ OR ‘exosomes’] AND [‘running’ ‘treadmill’ ‘marathon’] according PRISMA guidelines. selected studies that assessed numbers or size response running humans. Conference abstracts, reviews, published languages other than English, assessing any components without isolation, experimental animal models were excluded. There nine (#1-9), with a total 152 runners, 30 marathon Running activities included treadmill test (#1-7) high intensity outdoor (#8, #9). The was observed during (#1, n=16), immediately after (#2, n=10; #3, n=12; #5, n=8; #7, n=19; #9, n=26), remained elevated within 90 min (#3, n=12) decreased overnight (#6, #8, n=27). no effect on #4 (n=9). Size-exclusion chromatography used for isolation (#2; #4), nanoparticle tracking analysis – quantification (#3-7) Western blotting - cargo (#2-4; #6-7). optimal timing running, although protocol standardization is needed. This work carried out support our ongoing research into runners urticaria.